P06756 | AlphaLasso

Domain	Eukaryota
Family	Hominidae
Species (Full Name)	Homo sapiens
Gene	ITGAV MSK8 VNRA VTNR
PFAM codes	PF00357, PF01839, PF08441, PF20805, PF20806
InterPro codes	IPR000413, IPR013517, IPR013519, IPR013649, IPR018184, IPR028994, IPR032695, IPR048285, IPR048286
PDB structures (whole Protein)	1JV2 A: 31-987 1L5G A: 31-987 1M1X A: 31-987 1U8C A: 31-987 3IJE A: 31-997 4G1E A: 31-989 4G1M A: 31-989 4MMX A: 31-989 4MMY A: 31-989 4MMZ A: 31-989 4O02 A: 31-992 4UM8 A/C: 31-625 4UM9 A/C: 31-625 5FFG A: 31-625 5FFO A/E: 31-625 5NEM A: 31-624 5NER A: 31-624 5NET A: 31-624 5NEU A: 31-624 6AVQ A: 31-987 6AVR A: 31-987 6AVU A: 31-987 6DJP A: 31-995 6MK0 A: 31-984 6MSL A: 31-997 6MSU A: 31-997 6NAJ A: 31-984 6OM1 A/C/E/G: 31-624 6OM2 A/C: 31-624 6UJA A: 31-1048 6UJB A: 31-1048 6UJC A: 31-1048 7Y1T A: 1-625 8TCF A: 31-473 8TCG A: 31-469

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similar chains with experimentally solved models (PDB) in the AlphaLasso database (?% sequence similarity)

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similar chains with experimentally solved models not found in AlphaLasso database but found in thePDB database (?% sequence similarity)

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LL4,3

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Protein name	Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
Global pLDDT	88.29
Species	Human
UniProt	P06756
Structure Prediction Model	AlphaFold v4: P06756
PDB structures	1JV2 A 1L5G A 1M1X A 1U8C A 3IJE A 4G1E A 4G1M A 4MMX A 4MMY A 4MMZ A 4O02 A 4UM8 A/C 4UM9 A/C 5FFG A 5FFO A/E 5NEM A 5NER A 5NET A 5NEU A 6AVQ A 6AVR A 6AVU A 6DJP A 6MK0 A 6MSL A 6MSU A 6NAJ A 6OM1 A/C/E/G 6OM2 A/C 6UJA A 6UJB A 6UJC A 7Y1T A 8TCF A 8TCG A
AlphaKnot	P06756 3₁
Model length	1048
AlphaFold deposition date	2022-09-30
AlphaLasso deposition date	2024-04-15

Lasso types & Model sequence

			Bridge type			DeepShallow Lasso pLDDT	Global pLDDT	N-end GLN	C-end GLN	Loop range	Loop Length	N-term crossings	C-term crossings	N-end length	C-end length	Loop area
						82.3682.36	88.29	-0.922	-0.937	852-914	63	-778, +807, -829, +842 -778, +807, -829, +842	-929, +950, -978 -929, +950, -978	851	134	1621
						NoneNone	88.29	-0.069	-0.069	89-97	9			88	951	60

Model Sequence

MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET

Lasso diagram

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Comments

P06756 F1

LL4,3

Model Sequence