P08514 | AlphaLasso

Domain	Eukaryota
Family	Hominidae
Species (Full Name)	Homo sapiens
Gene	ITGA2B GP2B ITGAB
PFAM codes	PF00357, PF01839, PF08441, PF20805, PF20806
InterPro codes	IPR000413, IPR013517, IPR013519, IPR013649, IPR018184, IPR028994, IPR032695, IPR048285, IPR048286
PDB structures (whole Protein)	1DPK A: 1020-1039 1DPQ A: 1020-1039 1KUP A: 1018-1028 1KUZ A: 1018-1028 1M8O A: 1020-1039 1S4W A: 1020-1039 1TYE A/C/E: 32-483 2K1A A: 989-1029 2K9J A: 989-1029 2KNC A: 991-1039 2MTP B: 1019-1039 2N9Y A: 989-1029 2VC2 A: 32-483 2VDK A: 32-483 2VDL A: 32-483 2VDM A: 32-483 2VDN A: 32-483 2VDO A: 32-483 2VDP A: 32-483 2VDQ A: 32-483 2VDR A: 32-483 3FCS A/C: 32-989 3FCU A/C/E: 32-488 3NID A/C: 32-488 3NIF A/C: 32-488 3NIG A/C: 32-488 3T3M A/C: 32-488 3T3P A/C: 32-488 3ZDX A/C: 32-488 3ZDY A/C: 32-488 3ZDZ A/C: 32-488 3ZE0 A/C: 32-488 3ZE1 A/C: 32-488 3ZE2 A/C: 32-488 4CAK A: 32-989 4Z7N A/C: 32-486 4Z7O A/C: 32-486 4Z7Q A/C: 32-485 5HDB A/C: 32-485 6V4P A: 1-963 7KN0 A: 989-1029 7L8P A/C: 32-488 7LA4 A: 1-1039 7SC4 A/B: 1019-1039 7SFT B: 1019-1039 7TCT A/C: 32-488 7TD8 A/C: 32-484 7THO A/C: 32-485 7TMZ A/C: 32-485 7TPD A/C: 32-488 7U60 A/C: 32-486 7U9F A/C: 32-485 7U9V A/C: 32-485 7UBR A/C: 32-485 7UCY A/C: 32-488 7UDG A/C: 32-488 7UDH A/C: 32-488 7UE0 A/C: 32-488 7UFH A/C: 32-488 7UH8 A/C: 32-488 7UJE A/C: 32-485 7UJK A/C: 32-488 7UK9 A/C: 32-488 7UKO A/C: 32-488 7UKP A/C: 32-488 7UKT A/C: 32-488 8T2U A: 32-1039 8T2V A: 32-1039

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similar chains with experimentally solved models not found in AlphaLasso database but found in thePDB database (?% sequence similarity)

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LL4,3

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Protein name	Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alp...
Global pLDDT	88.28
Species	Human
UniProt	P08514
Structure Prediction Model	AlphaFold v4: P08514
PDB structures	1DPK A 1DPQ A 1KUP A 1KUZ A 1M8O A 1S4W A 1TYE A/C/E 2K1A A 2K9J A 2KNC A 2MTP B 2N9Y A 2VC2 A 2VDK A 2VDL A 2VDM A 2VDN A 2VDO A 2VDP A 2VDQ A 2VDR A 3FCS A/C 3FCU A/C/E 3NID A/C 3NIF A/C 3NIG A/C 3T3M A/C 3T3P A/C 3ZDX A/C 3ZDY A/C 3ZDZ A/C 3ZE0 A/C 3ZE1 A/C 3ZE2 A/C 4CAK A 4Z7N A/C 4Z7O A/C 4Z7Q A/C 5HDB A/C 6V4P A 7KN0 A 7L8P A/C 7LA4 A 7SC4 A/B 7SFT B 7TCT A/C 7TD8 A/C 7THO A/C 7TMZ A/C 7TPD A/C 7U60 A/C 7U9F A/C 7U9V A/C 7UBR A/C 7UCY A/C 7UDG A/C 7UDH A/C 7UE0 A/C 7UFH A/C 7UH8 A/C 7UJE A/C 7UJK A/C 7UK9 A/C 7UKO A/C 7UKP A/C 7UKT A/C 8T2U A 8T2V A
AlphaKnot	P08514 3₁
Model length	1039
AlphaFold deposition date	2022-09-30
AlphaLasso deposition date	2024-04-14

Lasso types & Model sequence

			Bridge type			DeepShallow Lasso pLDDT	Global pLDDT	N-end GLN	C-end GLN	Loop range	Loop Length	N-term crossings	C-term crossings	N-end length	C-end length	Loop area
						78.1878.18	88.28	-0.857	-0.937	857-921	65	-789, +811, -834, +846 -789, +811, -834, +846	-937, +953, -985 -937, +953, -985	856	118	2001
						NoneNone	88.28	-0.129	-0.081	87-96	10			86	943	87

Model Sequence

MARALCPLQALWLLEWVLLLLGPCAAPPAWALNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQEQTRIVLDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCELGNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSDLLYILDIQPQGGLQCFPQPPVNPLKVDWGLPIPSPSPIHPAHHKRDRRQIFLPEPEQPSRLQDPVLVSCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLEEDDEEGE

Lasso diagram

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Comments

P08514 F1

LL4,3

Model Sequence